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A 520-genome study finds shared mutation patterns in oesophageal cancers

A medRxiv preprint analysing 520 tumour genomes from eight countries reports similar mutational landscapes in oesophageal and gastroesophageal-junction adenocarcinomas. It also links reflux-associated mutation signatures with obesity in oesophageal adenocarcinoma and reports geographic differences in other signatures.

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Very hot drinks linked to higher oesophageal SCC risk in UK cohort study

A UK analysis of around 980,000 adults found that people reporting six or more cups of tea or coffee at “very hot” temperatures had three times the risk of oesophageal squamous cell carcinoma compared with those reporting warm drinks. The result came from more than 10 years of health-record follow-up and describes an association.