health
Preprint identifies how an anti-HPA-1a antibody activates platelets
A bioRxiv preprint describes two patient-derived anti-HPA-1a antibodies and finds that one induced platelet aggregation through coordinated binding to HPA-1a and FcγRIIa. The laboratory study provides a mechanistic explanation for functional differences among antibodies involved in fetal and neonatal alloimmune thrombocytopenia.