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Khabre desk
Recent reporting, analysis and explainers from the preclinical-research desk.
health
A bioRxiv preprint reports that mutations tuning complement activity changed how selected monoclonal antibodies protected neonatal mice from lethal HSV-1 infection. The effects varied with the antibody and its viral target.
health
A bioRxiv preprint reports that ANO6 helps organize contacts between the endoplasmic reticulum and mitochondria, directing vulnerable lipids into protective droplets in chemoresistant breast cancer models. Disrupting the system with niclosamide resensitized models to ferroptosis.
health
A bioRxiv preprint reports that MK2-deficient mice had more persistent colonic inflammation after chemical injury and produced fewer pro-resolving lipid mediators. Giving these mediators during recovery improved several measures of healing in the mice.
health
A bioRxiv preprint reports that CD19-targeted engineered regulatory T cells persisted for more than four months and reduced several measures of lupus in two mouse models. The findings are preclinical, not results from patients.
health
A bioRxiv preprint reports that genetic and drug-based SARM1 inhibition protected axons in mouse models relevant to multiple sclerosis. The drug preserved visual function without preventing demyelination.
health
A bioRxiv preprint reports that engineered Salmonella strain AD51, combined with intratumoral IFNγ, reduced tumour burden in mouse ovarian cancer and melanoma models. The findings are preclinical.
health
A bioRxiv preprint reports that harmine plus exendin-4, given after low-dose anti-CD3 therapy, promoted remission in diabetic mice. Human cell experiments also showed effects on beta-cell function and immune responses.