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KRAS preprint reports three modes of allosteric control

A bioRxiv preprint maps two distant binding sites in the cancer-associated protein KRAS and reports three forms of allosteric control: coupled, anti-coupled and independent. The finding suggests that a single protein can contain multiple regulatory networks with potential implications for drug design.

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Generative model CELL-FM links protein sequences to microscopy images

A UCSF-led bioRxiv preprint introduces CELL-FM, a bidirectional generative model that connects protein sequences and cellular context with fluorescence microscopy images. The authors use it for virtual localization, motif analysis and mutagenesis of intrinsically disordered peptides.