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Khabre desk
Recent reporting, analysis and explainers from the protein-design desk.
science
Researchers used generative protein design and directed evolution to create artificial metalloenzymes that control the stereochemistry of light-driven reactions. The study reports diverse reactions, catalyst recycling and high turnover.
science
A bioRxiv preprint introduces Chaperone, a framework for coordinating protein-design tools. Its authors report reduced token use and GPU costs across nine design tasks, alongside results from several protein-design campaigns.
science
A bioRxiv preprint describes MIMOSA, a framework that guides antibody-generating models using the structure of a known binder interface. The authors report experimentally validated binders against three targets, with hit rates of 20–26%.
technology
Anthropic says Claude Fable 5.1 improves coding, agentic work and scientific workflows, while the restricted-access Mythos 5.1 uses the same underlying model with different safeguards.
science
Apple researchers describe SimpleDesign, a Transformer-based model that jointly generates protein sequences and three-dimensional structures using a single-stage training approach. The system was trained on more than 2 million sequence–structure pairs, but the supplied evidence reports no experimental validation of its designs.