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Khabre desk
Recent reporting, analysis and explainers from the protein structure desk.
health
A medRxiv preprint reports that RNF213 activity is regulated by a switch between closed and open protein dimers. The authors say Moyamoya-associated mutations can destabilise the closed state and bypass this control in laboratory experiments.
science
A bioRxiv preprint presents SGFP–G, a split-GFP graphene grid that selectively captures GFP11-tagged proteins and lets researchers check enrichment by fluorescence before vitrification. The authors demonstrated the platform with apoferritin and obtained a 2.58 Å cryo-EM reconstruction.