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Khabre desk
Recent reporting, analysis and explainers from the proteomics desk.
health
A Nature Medicine study identified menopause-related blood protein patterns associated with hormonal changes, brain aging and less favourable cognitive outcomes later in life. The observational findings provide a research framework for studying how the menopause transition may intersect with dementia risk.
health
A medRxiv preprint analysed 344 postoperative drain-fluid samples from 67 pancreatic and colorectal surgery patients. It found that leakage was associated with different protein patterns over time in the two types of surgery.
health
A medRxiv preprint used proteome-wide Mendelian randomization to identify 11 plasma proteins associated with early-onset stroke, defined as stroke occurring before age 60. The strongest signals involved coagulation and thromboinflammatory pathways, with Factor XI highlighted as a potential therapeutic target.
science
Researchers mapped 4,321 microproteins in 608 post-mortem human brain samples, including dozens with altered expression in Alzheimer’s disease. The atlas expands the molecular inventory available for studying neurodegeneration, while the proteins’ biological roles still require experimental validation.
health
A medRxiv preprint reports that altered placental LBX1 was associated with spontaneous preterm birth in analyses of 70 placentae and 53 maternal plasma samples. Cell findings suggest a pathway involving nuclear import, ribosomal disruption and the unfolded protein response.
science
A Nature study analysed a large-scale proteogenomic dataset from 29 healthy human tissues and identified 13,910 protein variants, including non-genetic amino-acid substitutions. The findings suggest that errors and variation during protein production may expand the set of protein forms with potential biological functions.