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Khabre desk
Recent reporting, analysis and explainers from the RNA biology desk.
science
A bioRxiv preprint describes miRstring, a biogenesis-aware RNA language model trained on 77,708 miRNA precursors from 414 species. The authors report cross-species mature-miRNA boundary decoding and artificial miRNA scaffold designs that repressed target mRNAs in validation experiments.
science
A bioRxiv preprint describes RNA-fragment end joining (REJ), a modular system that joins separate RNA units into functional coding mRNAs. The reported platform supports gene complementation, intersectional cell labeling and expression of large proteins.
science
A bioRxiv preprint describes Isocall, a deterministic method for jointly identifying known and novel transcripts across large PacBio long-read RNA-sequencing datasets. The authors report a joint call across 206 samples in 25 minutes after alignment and profiling.
science
A bioRxiv preprint introduces RADIS, a chemical-probing strategy that maps RNA secondary structure across long, intron-rich genomic loci. The study applies it to splice sites, branchpoints and Alu elements, including deep intronic regions that are difficult to analyse experimentally.