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Khabre desk
Recent reporting, analysis and explainers from the single-cell sequencing desk.
science
A bioRxiv preprint presents a 658,059-cell reference atlas of human hippocampus development and uses it to study brain organoids carrying the familial Alzheimer’s disease-associated PSEN1 E280A variant. The organoids showed altered cell composition, gene expression and inferred neuronal maturation.
science
A University of Michigan team has introduced AmbientMapper, a computational method that estimates ambient chromatin contamination in combinatorial single-cell experiments. In a bioRxiv preprint, the authors report a 0.19% wrong-genome rate on a 26-genome reference panel and recovery of low-depth nuclei that standard pipelines discarded.