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Khabre desk
Recent reporting, analysis and explainers from the single-cell-sequencing desk.
health
A single-nucleus atlas of colorectal tumours found a higher stromal-to-epithelial ratio in younger patients with microsatellite-stable cancer. The study also identified age-associated RNA signals and differences in computationally inferred cell communication.
health
A study of 62 pancreatic ductal adenocarcinomas found genetically distinct clones within tumours and linked MYC amplification to shifts between tumour cell states. Experiments in murine and primary human models showed that reducing MYC reactivated classical gene-expression and immune-response programs.
science
A bioRxiv preprint describes BEACON, a method that learns background count patterns to assign single cells to their samples in multiplexed sequencing. The authors report improved classification across human datasets and applications in cancer-cell experiments and protein–transcriptome profiling.