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Khabre desk
Recent reporting, analysis and explainers from the single-molecule biophysics desk.
science
A bioRxiv preprint describes ModDNA, a sequence-design and cloning toolkit for building custom DNA molecules up to 100 kilobases. The researchers used the constructs in single-molecule visualisation assays, including an assay of DNA loop extrusion by human condensin I.
science
A bioRxiv preprint introduces fp-SMD, which models the optically trapped bead, linker and biomolecule together. The authors report that it reproduces a cholesterol–β-cyclodextrin rupture-force histogram and captures force-dependent changes in the molecule’s escape route.