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Khabre desk
Recent reporting, analysis and explainers from the spatial-transcriptomics desk.
science
A bioRxiv preprint reports that tumour-cell states, mutations, tumour architecture and immune signals were associated with differences in ctDNA release in ten patients with non-metastatic HR+/HER2− breast cancer. The findings offer a biological framework for understanding why tumour DNA detected in tissue may differ from what appears in blood.
science
A bioRxiv preprint describes MCseg, a no-code tool whose segmentation workflow was selected through AI-agent-guided searches. In a lung adenocarcinoma dataset, its fixed-parameter workflow scored higher on panoptic quality than an Optuna-tuned Cellpose baseline.
health
A bioRxiv preprint uses spatial multi-omics and 3D imaging to map melanoma tumours treated with neoadjuvant immunotherapy. The study links organised immune structures, including tertiary lymphoid structures and germinal centres, with treatment response and disease-free survival.
science
A bioRxiv preprint introduces CynoBrain, a macaque brain atlas that combines 9.4-tesla MRI, autofluorescence, cortical layers, gene-expression data and neural connectivity in one reference space. The authors also describe an online platform for exploring and integrating the data.