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Khabre desk
Recent reporting, analysis and explainers from the structural biology desk.
science
A bioRxiv preprint reports cryo-EM structures showing aphidicolin blocking human DNA polymerases δ and ε at the site where they add DNA building blocks. Reconstituted assays and the structures suggest that differences in how the enzymes grip the DNA template help explain why Pol δ is more sensitive.
science
A bioRxiv preprint reports cryo-EM structures of human VIAAT in two states, identifying a GABA-binding pocket and a proposed gate that opens toward the synaptic-vesicle interior.
science
A bioRxiv preprint maps how cryogenic focused ion beam milling affects structural preservation at different depths. The apparent damage profile varied with the ion species, molecular reporter and lamella thickness.
science
A bioRxiv preprint reports the first three-dimensional structure of a class II GalT enzyme from Bifidobacterium longum at 2.25 Å resolution. The study links its unusual architecture to a preference for N-acetylated sugars involved in human milk oligosaccharide metabolism.
science
A bioRxiv preprint presents a machine-learning structural atlas of kinase inhibitor binding sites, built from 11,945 inhibitor complexes. The analysis suggests that evolutionary relationships between kinases can help predict shared access to allosteric drug pockets.