structural biology

science

Cryo-FIB damage varies by molecular target, preprint finds

A bioRxiv preprint maps how cryogenic focused ion beam milling affects structural preservation at different depths. The apparent damage profile varied with the ion species, molecular reporter and lamella thickness.

2026-09-19T03:16:09+05:30

science

Preprint reveals structure of Bifidobacterium enzyme in milk-sugar metabolism

A bioRxiv preprint reports the first three-dimensional structure of a class II GalT enzyme from Bifidobacterium longum at 2.25 Å resolution. The study links its unusual architecture to a preference for N-acetylated sugars involved in human milk oligosaccharide metabolism.

2026-09-18T05:53:43+05:30

science

Machine-learning atlas maps allosteric pockets across the human kinome

A bioRxiv preprint presents a machine-learning structural atlas of kinase inhibitor binding sites, built from 11,945 inhibitor complexes. The analysis suggests that evolutionary relationships between kinases can help predict shared access to allosteric drug pockets.

2026-09-14T11:16:29+05:30