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Khabre desk
Recent reporting, analysis and explainers from the synthetic-biology desk.
science
A bioRxiv preprint describes DS3dRNA, a method that scores interactions among groups of RNA structural elements to design sequences for target structures. The authors report improved benchmark performance and experimental activity in designed Mango II and twister RNAs.
health
A bioRxiv preprint reports that engineered Salmonella strain AD51, combined with intratumoral IFNγ, reduced tumour burden in mouse ovarian cancer and melanoma models. The findings are preclinical.
science
A bioRxiv preprint introduces ProFinder, a computational tool that ranks candidate constitutive promoters in bacterial genomes. The authors report generating candidates for 99.76% of 56,742 genomes spanning 149 phyla.
science
A bioRxiv preprint reports valerolactam production in engineered Corynebacterium glutamicum, reaching 3.6 g/L after pathway design and fed-batch process optimization.