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Khabre desk
Recent reporting, analysis and explainers from the transcriptomics desk.
health
A Nature Medicine research briefing reports that colorectal tumours in younger adults contain more stromal cells and show higher expression of long non-coding RNAs and genes linked to epithelial-to-mesenchymal transition. The findings come from a transcriptomic atlas mapping tumours across the age continuum.
science
A bioRxiv preprint reanalysed 115 whole-body RNA-sequencing libraries from female Anopheles gambiae kept at 27, 30 or 32°C. A gene-expression clock estimated warmer mosquitoes as older, but its age offset stopped widening after day five.
science
A bioRxiv preprint analysing a PLP1-mutant Jimpy brain dataset finds that normalization choices and shared controls can affect which genes appear to move toward healthy levels after a rescue. The authors say such transcriptomic patterns can indicate broad state restoration without identifying which downstream gene mediates it.
science
A bioRxiv preprint uses single-cell transcriptomics to reconstruct an unusual anaerobic mitochondrion in the rhizarian flagellate PCE SSF. The proposed metabolism includes hydrogen production and a reduced, branched pathway for processing carbon.
science
A bioRxiv preprint describes Isocall, a deterministic method for jointly identifying known and novel transcripts across large PacBio long-read RNA-sequencing datasets. The authors report a joint call across 206 samples in 25 minutes after alignment and profiling.