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Khabre desk
Recent reporting, analysis and explainers from the virology desk.
science
A bioRxiv preprint comparing human H1N1 strains collected from 1977 to 2024 reports a recurring preference for α2,6-sialylated glycans. The study also found changes in binding avidity and a binding-null egg-adapted mutant.
science
A bioRxiv preprint reports that the host protein HNRNPM binds stem-loop 5 in the SARS-CoV-2 5′-UTR and promotes protein synthesis from the viral RNA. Mutations in the structure’s lower stem reduced both HNRNPM binding and protein synthesis.
science
A bioRxiv preprint reports H5N1 and H5N5 infections in six red foxes in Norway between 2022 and 2024. The investigation found systemic infection and detected a mammalian-adaptation marker in two H5N1 viruses.
health
A bioRxiv preprint reports that a hepatitis B virus basal core promoter mutation increased viral activity in human-hepatocyte chimeric mice, with effects that varied by viral genotype. Analysis of human liver-tumour datasets also found distinct gene-expression profiles associated with the mutation.
science
A bioRxiv preprint reports a previously uncharacterised porcine adenovirus in a New Zealand high-health pig herd affected by neonatal deaths and reproductive problems. Genome sequencing placed the virus in the Mastadenovirus genus but on a distinct lineage from characterised porcine adenoviruses.