Khabre branded placeholder image

health

UK Biobank Study Finds Greater Structural Vulnerability in Basal Forebrain Ch4

A medRxiv preprint analysing 81,870 UK Biobank participants found that structural deviations with ageing and neurological disease were concentrated in the basal forebrain’s Ch4 compartment. The study also linked Ch4 deficits with later dementia and Parkinson’s disease diagnoses.

Khabre branded placeholder image

health

First mutation-targeted RNA therapy improves rare ALS case

A man with slowly progressing ALS caused by a rare CHCHD10 mutation showed improved motor-function scores and a biomarker associated with nerve damage returned to the normal reference range one year after receiving a mutation-targeted antisense oligonucleotide treatment.

Khabre branded placeholder image

health

Preprint reports brain changes in asymptomatic female XDP carriers

A medRxiv preprint reports striatal atrophy and increased caudate iron accumulation in asymptomatic female carriers of the genetic variant associated with X-linked dystonia-parkinsonism. The findings came from multimodal MRI in 42 carriers compared with 61 healthy controls.