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MRI psychosis-risk model performs weakly across four cohorts

A medRxiv preprint tested a structural MRI model for psychosis risk across four independent clinical high-risk cohorts. Its discrimination was weak, predicted risks transferred poorly, and exploratory analyses found variation by negative-symptom severity.

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Review finds mental-health outcomes vary across autistic people

A medRxiv systematic review of 39 studies found that mental-health treatment outcomes for autistic people varied by intervention. Where significant differences were reported, they generally involved smaller improvements rather than no benefit.

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North India preprint links youth victimisation to suicidal behaviour

A medRxiv preprint based on 752 young adults in a North Indian city found that victimisation was indirectly associated with suicidal ideation and attempts through physical violence and depressive symptoms. The study used a structural equation model to examine these pathways.

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Preprint reports sleep odour cues improving PTSD therapy

A medRxiv preprint reports that repeated odour cues delivered during sleep improved PTSD symptoms and accelerated treatment response when paired with 12 weeks of trauma-focused psychotherapy. The findings combine a mechanistic study in healthy participants with a randomized clinical trial.