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Claims study estimates 0.43% 45-day serious-event risk after mifepristone use

A medRxiv preprint analysing 2017–2023 claims data reports that 0.43% of mifepristone uses in its medication-abortion cohort were followed by a serious adverse event within 45 days. The retrospective study classified outcomes using claims-based criteria aligned with FDA seriousness criteria.

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Preprint builds a pregnancy register from Greater Manchester care records

A medRxiv preprint describes an algorithm that identified 880,926 pregnancies in Greater Manchester primary-care records. Validation results varied by outcome, with a substantial gap between the register’s miscarriage and termination rates and published UK estimates.

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Mouse preprint identifies neurons required for viable pregnancy

A bioRxiv preprint reports that pregnancy changes gene expression in several hormone-sensitive brain-cell populations in mice. Removing one neuronal type prevented implantation and viable pregnancy in the animals studied.