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Khabre desk
Recent reporting, analysis and explainers from the Cardiovascular Medicine desk.
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A medRxiv preprint links ASXL1-mutant clonal haematopoiesis with aortic stenosis in human cohorts and reports enhanced calcification in a cultured-cell model. In laboratory experiments, blocking IL-1 or IL-6 reduced calcification.
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A medRxiv preprint identifies a MYOF missense variant associated with arrhythmogenic cardiomyopathy and describes a calcium-handling mechanism in patient-derived heart cells and mice. The findings point to the MYOF–CaV1.2 pathway as a potential therapeutic target, but remain preclinical.
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A single-centre retrospective preprint found that modified Morrow myectomy produced lower one-year LVOT gradients, while Liwen ablation was associated with fewer new conduction abnormalities and shorter procedures and hospital stays. The authors describe the findings as a trade-off requiring prospective confirmation.