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Preprint links MYOF variant to arrhythmogenic cardiomyopathy

A medRxiv preprint identifies a MYOF missense variant associated with arrhythmogenic cardiomyopathy and describes a calcium-handling mechanism in patient-derived heart cells and mice. The findings point to the MYOF–CaV1.2 pathway as a potential therapeutic target, but remain preclinical.

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Preprint Finds a Trade-Off Between Liwen Ablation and Myectomy in HCM

A single-centre retrospective preprint found that modified Morrow myectomy produced lower one-year LVOT gradients, while Liwen ablation was associated with fewer new conduction abnormalities and shorter procedures and hospital stays. The authors describe the findings as a trade-off requiring prospective confirmation.