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CA-125 Sugar Variant Linked to Ovarian Cancer Years Before Diagnosis

A Swedish case-control study found that a specific sugar-modified form of CA-125 was associated with ovarian cancer diagnosed several years later. The preprint suggests a possible early-risk signal, but larger studies using repeated samples are needed.

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Alzheimer’s risk reflects both brain pathology and cognitive resilience

A longitudinal study of 3,119 older adults found that Alzheimer’s disease dementia risk was associated independently with pathological burden and cognitive resilience. The two factors also interacted, with the highest risk among people with high pathology and low resilience.