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Khabre desk
Recent reporting, analysis and explainers from the Antimicrobial Resistance desk.
health
A bioRxiv preprint reports that ciprofloxacin resistance mutations selected in laboratory experiments largely matched those found in in vivo data for E. coli and P. aeruginosa. The authors say this supports using experimental evolution to help forecast resistance risks, while noting that other bacteria–drug combinations need study.
health
A bioRxiv preprint reports that the bacterial enzyme LysM can kill several Gram-negative hospital pathogens and disrupt their biofilms, particularly when combined with EDTA. Tests included laboratory experiments and a human airway organoid model, not treatment in patients.
health
A bioRxiv preprint analysing 20,331 E. coli genomes identifies ST361 as an emerging carbapenem-resistant clone associated with urinary tract infection. The researchers also link its common surface-polysaccharide type to virulence in mouse infection models.
health
A bioRxiv preprint found that many capsule types in Pakistani carbapenem-resistant Klebsiella pneumoniae genomes have no phage described in the literature. It identifies the South Asian capsule type KL81 as a target for future phage-isolation work.