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Khabre desk
Recent reporting, analysis and explainers from the Cancer Biology desk.
health
A bioRxiv preprint reports that ANO6 helps organize contacts between the endoplasmic reticulum and mitochondria, directing vulnerable lipids into protective droplets in chemoresistant breast cancer models. Disrupting the system with niclosamide resensitized models to ferroptosis.
health
A bioRxiv preprint reports that the RAF inhibitor ELV-3111, combined with a MEK inhibitor, suppressed MAPK signalling and produced tumour regressions in RAS- and BRAF-mutant models. The findings describe preclinical research, not patient outcomes.
health
A bioRxiv preprint associates a platelet-related circulating tumour-cell profile in breast cancer with poorer overall survival. It also proposes a CD40LG–ITGA5:ITGB1 signal involving monocytes as a candidate for further study.