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Khabre desk
Recent reporting, analysis and explainers from the Cancer Research desk.
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A study of 62 pancreatic ductal adenocarcinomas found genetically distinct clones within tumours and linked MYC amplification to shifts between tumour cell states. Experiments in murine and primary human models showed that reducing MYC reactivated classical gene-expression and immune-response programs.
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A bioRxiv preprint describes NeoOmni Atlas, a database built by reanalysing mass-spectrometry data from 26 cancer types. It catalogues HLA-presented peptides and computationally prioritises potential tumour-associated and tumour-specific targets.
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A bioRxiv preprint describes HistoProfile, an AI model that estimates immune-marker measurements from routine cancer tissue slides. The authors report AUROCs of 0.78–0.89 for distinguishing biomarker-high from biomarker-low tumours.
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A bioRxiv preprint reports four genomic subtypes of mucosal melanoma and immune-cell patterns associated with disease progression and immunotherapy resistance. The findings point to TIM-3 as a possible research target, not an established treatment.
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A bioRxiv preprint reports that reducing the catalytic activity of immunotoxin payloads improved selectivity between receptor-high and receptor-low cells. In an in vivo HER2-targeted test, the attenuated version had a 400-fold higher maximum tolerated dose than its wild-type counterpart.
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A bioRxiv preprint reports that plasma mass spectrometry could detect some tumor-associated peptides, but neoepitope searches were constrained by limited overlap between cfDNA and tumor mutations and by MS sensitivity. Tissue remained the stronger reference for identifying tumor mutations and neoepitopes.
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A bioRxiv preprint reports that engineered Salmonella strain AD51, combined with intratumoral IFNγ, reduced tumour burden in mouse ovarian cancer and melanoma models. The findings are preclinical.
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A bioRxiv preprint reports that changes involving DNMT1 can reduce CTCF binding at the KMT2A gene and promote copy gains and rearrangements. The findings come from experimental molecular research, not a clinical study.
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A bioRxiv preprint uses spatial multi-omics and 3D imaging to map melanoma tumours treated with neoadjuvant immunotherapy. The study links organised immune structures, including tertiary lymphoid structures and germinal centres, with treatment response and disease-free survival.