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Khabre desk
Recent reporting, analysis and explainers from the Liver Disease desk.
health
A bioRxiv preprint links the mitochondrial protein OPA1 to liver fibrosis through human MASLD analyses and experiments in mice. The mouse findings connect loss of OPA1 in liver cells with stellate-cell activation and fibrosis.
health
A bioRxiv preprint links neutrophil alpha-defensins to mitochondrial changes and fat accumulation in liver cells. The proposed pathway is supported by cell experiments and a mouse model, while the patient findings are correlational.
health
A bioRxiv preprint reports that a hepatitis B virus basal core promoter mutation increased viral activity in human-hepatocyte chimeric mice, with effects that varied by viral genotype. Analysis of human liver-tumour datasets also found distinct gene-expression profiles associated with the mutation.