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Khabre desk
Recent reporting, analysis and explainers from the Neuroscience desk.
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A bioRxiv preprint reports that deleting truncated TrkB receptors in astrocytes reduced amyloid plaques and preserved synaptic markers in 5xFAD mice. The findings are from a mouse model, not a human treatment study.
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A bioRxiv preprint reports that a cerebrospinal-fluid-delivered siRNA reduced prion protein to 12% residual levels in mouse brain and kept early-treated, prion-infected mice symptom-free through 500 days after inoculation. The researchers also report activity in humanized mice and cynomolgus macaques.
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A bioRxiv preprint reports that NOSTRA, a small molecule found through a DNA-encoded library screen, stabilises the NOS1AP–SCRIB interaction. In Alzheimer’s patient-derived neurons, the researchers report changes in several cellular measures, including amyloid-beta ratio, p-tau217 and network activity.
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A bioRxiv preprint reports that genetic and drug-based SARM1 inhibition protected axons in mouse models relevant to multiple sclerosis. The drug preserved visual function without preventing demyelination.
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A bioRxiv preprint reports that restoring several TDP-43 cryptic targets, including Unc13a, protected spinal motor neurons in a mouse model of early-stage ALS more effectively than targeting Unc13a alone.