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Khabre desk
Recent reporting, analysis and explainers from the Oncology desk.
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A single-nucleus atlas of colorectal tumours found a higher stromal-to-epithelial ratio in younger patients with microsatellite-stable cancer. The study also identified age-associated RNA signals and differences in computationally inferred cell communication.
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Nature Medicine has issued an expression of concern over image irregularities in a 2014 study of gastrointestinal organoids. The editors advise caution about specified images while saying the study’s main conclusions appear supported by its other data.
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A longitudinal study linked routine clinical records from 52,236 adults with cancer to identify recurring episodes of significant weight loss. The episodes clustered around disease progression and were associated with consistent blood-marker changes and several tumor mutations.
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A Nature Medicine study links levetiracetam use with longer survival in children with diffuse midline glioma and reports reduced tumour growth in mouse models. The findings point to a tumour-selective effect on GABAergic neuron-to-glioma synapses and require prospective clinical testing.
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Nature Medicine has issued an Editorial Expression of Concern about a 2015 letter on EZH2 dependence in SWI/SNF-mutant cancers. The notice identifies similarities in several figure panels and says the original data are no longer available.