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Khabre desk
Recent reporting, analysis and explainers from the Infectious Diseases desk.
health
A statistical model estimated that testing for recent tuberculosis infection could reduce the median number of people needed for a vaccine trial by 4.2- to 6-fold compared with long-lasting IGRA positivity under favourable conditions. The estimates are preprint model results, and the authors say candidate tests still need to be characterised.
health
A medRxiv preprint pooling two randomized trials found no statistically significant difference in 90-day mortality between intravenous cefazolin and antistaphylococcal penicillins for adults with MSSA bacteremia. Estimates for kidney injury and treatment discontinuation favoured cefazolin in direction but were imprecise.
health
A medRxiv preprint reports improved clinical outcomes and changes in immune markers after N-acetylcysteine treatment in cancer patients with severe COVID-19. The clinical comparison used severity-matched patients treated before the trial began.