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Study reconstructs widespread physiological shifts around menopause

An analysis of more than 300 million laboratory tests reconstructed group-level changes around the final menstrual period and found step-like shifts across many body systems. The study also found hormone changes beginning more than a decade before that point and an observational association between menopausal hormone therapy and smaller shifts.

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Menopause Therapy’s Brain Associations Vary by Formulation and APOE ε4

A medRxiv preprint analysing 8,741 female participants older than 70 reports that associations between menopause hormone therapy, cognition and brain structure differed by treatment formulation and APOE ε4 status. Among APOE ε4 carriers, estradiol-based therapy was linked to more favourable cognitive and imaging measures than conjugated equine estrogens.