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Khabre desk
Recent reporting, analysis and explainers from the Oncology desk.
health
A prespecified five-year analysis of RELATIVITY-047 found lower hazards of progression and death with relatlimab plus nivolumab than with nivolumab alone. Exploratory biomarker analyses also linked higher LAG-3-positive CD8 cell levels to worse outcomes on nivolumab in a defined subgroup.
health
A phase 1 trial tested a personalized neoantigen vaccine after platinum chemotherapy in people with high-grade epithelial ovarian cancer. The researchers reported biological activity signals in six of 10 vaccinated patients, alongside immune responses in blood and tumour.
health
An international prospective study evaluated a blood assay that combines a 10-microRNA signature with carbohydrate antigen 19-9 for detecting early pancreatic ductal adenocarcinoma. The composite PANXEON score showed 86.8% sensitivity for stage I–II disease in the testing cohort, but the researchers say larger prospective studies are still needed.