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Khabre desk
Recent reporting, analysis and explainers from the Bioengineering desk.
science
A bioRxiv preprint describes four rounds of computational screening that identified natural hydroxymethylfurfural oxidases with improved activity on a key FDCA-production reaction. Some candidates approached an engineered benchmark under the tested conditions.
science
A bioRxiv preprint reports valerolactam production in engineered Corynebacterium glutamicum, reaching 3.6 g/L after pathway design and fed-batch process optimization.
science
A bioRxiv preprint describes a physics-based framework that combines machine learning, molecular mechanics and microkinetic modelling to predict enzyme reaction rates and selectivity. In tests on an oxidative amidase, the authors report near-experimental accuracy across substrates, mutations and enzyme homologues.