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Khabre desk
Recent reporting, analysis and explainers from the Biomedical Research desk.
science
Researchers tested a biodegradable battery made from body-compatible materials in two swallowable devices: an RFID transmitter and a stomach stimulator. The battery began breaking down in simulated gastric fluid within two weeks and dissolved completely after several months.
science
A bioRxiv preprint maps two distant binding sites in the cancer-associated protein KRAS and reports three forms of allosteric control: coupled, anti-coupled and independent. The finding suggests that a single protein can contain multiple regulatory networks with potential implications for drug design.
science
A bioRxiv preprint describes BiAb J31, an IgG-like bispecific antibody that links TNF-α to the endocytic receptor ASGPR1. In HepG2 cell experiments, the antibody recruited TNF-α-containing complexes and promoted their uptake.
science
A bioRxiv preprint describes a human stem-cell-derived nerve-like construct that supported axon regeneration and remyelination in 7-mm sciatic nerve defects in mice.
science
A bioRxiv preprint presents ForceFlowAb, a mixture-of-experts flow-matching model that designs antibody CDR sequences and structures with force-field guidance. The authors report more favourable antibody–antigen interaction-energy results than two comparison methods in CDR-H3 and six-CDR design tasks.
science
A bioRxiv preprint presents a machine-learning structural atlas of kinase inhibitor binding sites, built from 11,945 inhibitor complexes. The analysis suggests that evolutionary relationships between kinases can help predict shared access to allosteric drug pockets.
science
A bioRxiv preprint used giant unilamellar vesicles to visualise how two ionisable-lipid nanoparticles interact with model endosomal membranes. The results suggest that apparent pKa alone does not predict the pH at which functional membrane engagement occurs.
science
A bioRxiv preprint reports that people in windowless offices exposed to desk lamps supplemented with 850-nm near-infrared light had reduced glucose measurements over a three-day experiment, while standard LED exposure was associated with increased levels. The study used an oral glucose tolerance test and continuous glucose monitoring.