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Khabre desk
Recent reporting, analysis and explainers from the Biomedical Research desk.
science
Nature Medicine has issued an Editorial Expression of Concern over northern blot images in a 2007 paper on microRNA-133 and cardiac hypertrophy. The journal says the original data are no longer available and advises readers to interpret the affected data with caution.
science
A bioRxiv preprint describes three recurring leukaemia stem-cell states in paediatric acute myeloid leukaemia and reports that the surface antigens CLEC12A and CD84 together cover them broadly. The findings offer a target-selection framework for future immunotherapy research.
science
A bioRxiv preprint maps nucleosome patterns across 410 tumours from 23 cancer types and reports that tissue-derived patterns could distinguish cancers using circulating cell-free DNA. The findings point to a possible source of information for non-invasive cancer detection, but the reported results are from research analyses rather than a demonstrated clinical test.
science
A bioRxiv preprint describes PRIORITI, a framework that combines language-model synthesis of human genetic evidence with supervised learning to forecast whether a proposed drug target–disease pairing will succeed. The authors report results on historical and post-cutoff benchmark sets.
science
Researchers at OmiCore have released an openly licensed image-analysis model that marks tumour-enriched regions in colorectal cancer tissue slides. In a preprint, the team reports agreement with transcriptomics on one section and describes limits including its 112 μm resolution and lack of validation across scanners and institutions.
science
Nature Index data for 2016–2025 puts the United States first in regenerative-medicine research output, while China’s expansion could narrow the gap if it continues.
science
A bioRxiv preprint describes REAL-SWIT, a generative system for exploring make-on-demand chemical space. In experiments on ROCK1, six of 23 synthesized compounds inhibited the target in biochemical tests.
science
Researchers tested a biodegradable battery made from body-compatible materials in two swallowable devices: an RFID transmitter and a stomach stimulator. The battery began breaking down in simulated gastric fluid within two weeks and dissolved completely after several months.
science
A bioRxiv preprint maps two distant binding sites in the cancer-associated protein KRAS and reports three forms of allosteric control: coupled, anti-coupled and independent. The finding suggests that a single protein can contain multiple regulatory networks with potential implications for drug design.
science
A bioRxiv preprint describes BiAb J31, an IgG-like bispecific antibody that links TNF-α to the endocytic receptor ASGPR1. In HepG2 cell experiments, the antibody recruited TNF-α-containing complexes and promoted their uptake.
science
A bioRxiv preprint describes a human stem-cell-derived nerve-like construct that supported axon regeneration and remyelination in 7-mm sciatic nerve defects in mice.
science
A bioRxiv preprint presents ForceFlowAb, a mixture-of-experts flow-matching model that designs antibody CDR sequences and structures with force-field guidance. The authors report more favourable antibody–antigen interaction-energy results than two comparison methods in CDR-H3 and six-CDR design tasks.
science
A bioRxiv preprint presents a machine-learning structural atlas of kinase inhibitor binding sites, built from 11,945 inhibitor complexes. The analysis suggests that evolutionary relationships between kinases can help predict shared access to allosteric drug pockets.
science
A bioRxiv preprint used giant unilamellar vesicles to visualise how two ionisable-lipid nanoparticles interact with model endosomal membranes. The results suggest that apparent pKa alone does not predict the pH at which functional membrane engagement occurs.
science
A bioRxiv preprint reports that people in windowless offices exposed to desk lamps supplemented with 850-nm near-infrared light had reduced glucose measurements over a three-day experiment, while standard LED exposure was associated with increased levels. The study used an oral glucose tolerance test and continuous glucose monitoring.