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Khabre desk
Recent reporting, analysis and explainers from the Biophysics desk.
science
A bioRxiv preprint reports that centromeres in isolated human metaphase chromosomes have a distinct force response, including softening at some force levels. The researchers also found that topoisomerase IIα is recruited to centromeric regions under significant tension.
science
A bioRxiv preprint benchmarking differential scanning fluorimetry across 26 laboratories found good repeatability within instruments but moderate differences between them. The fluorescence readout and analysis workflow also affected apparent protein melting temperatures.
science
A bioRxiv preprint describes ModDNA, a sequence-design and cloning toolkit for building custom DNA molecules up to 100 kilobases. The researchers used the constructs in single-molecule visualisation assays, including an assay of DNA loop extrusion by human condensin I.
science
A bioRxiv preprint presents a physics-based framework that combines protein, nucleic-acid and metabolite models to simulate biomolecular condensates. Its authors report predictions for more than 60 disordered proteins and simulations of RNA- and protein–nucleic-acid condensates.
science
Researchers at King's College London report TomoFLIM, a compressed multiphoton fluorescence lifetime imaging method. In a preprint benchmark, it reproduced a 60-second raster-scanned dataset in 3.75 seconds.