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Khabre desk
Recent reporting, analysis and explainers from the Developmental Biology desk.
science
A bioRxiv preprint maps the maturation of human choroid-plexus organoids and reports that their response to valproic acid depends on developmental stage. Early changes recovered after the drug was withdrawn, while some late-stage transporter impairments persisted.
science
Mouse lineage-tracing experiments and human stem-cell differentiation studies indicate that the developing brain arises from two parallel neural ectoderm progenitors. The finding concerns embryonic cell lineages, not two physically separate adult organs.
science
A bioRxiv preprint reports that dermal bone thickens through invading osteoblasts that deposit new mineralised matrix inside older bone. The finding challenges the conventional view that growth relies mainly on bone-forming cells adding matrix at the surface.
science
A bioRxiv preprint analyses 435 thalidomide-affected limbs and proposes that the unusual order of bone reductions follows the sequential exit of developing bones from a sensitive window.