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Khabre desk
Recent reporting, analysis and explainers from the Neuroscience desk.
science
OpenAI says it worked with PerturbAI and Scripps Research to use thousands of GPT-Rosalind agents to analyse a whole-brain mouse CRISPR atlas in 32 minutes. The agents linked gene-disruption effects with scientific literature to produce leads for follow-up research.
science
A Nature correspondence links research into how single-celled algae sense light to the discovery of channelrhodopsins and the development of optogenetics. Its authors say this line of work underpins this year’s Nobel Prize in Physiology or Medicine.
science
A bioRxiv preprint reports that increased nuclear acetyl-CoA in lab-grown neurons from people with sporadic Alzheimer’s disease was linked to altered RNA-protein acetylation and splicing. Inhibiting the enzyme ACLY reversed these changes in the cell model.
science
A bioRxiv preprint reports that mice developed opioid-induced hyperalgesia even when spinal microglia were absent. The findings also separate changes in microglial appearance from a necessary role in the measured opioid effects.
science
A Nature editorial argues that brain-organoid research needs international oversight as human lab-grown brain tissue is integrated into animal brains. It points to independent, multidisciplinary ethics advisers as one way to guide research.