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Khabre desk
Recent reporting, analysis and explainers from the Bioinformatics desk.
science
A bioRxiv preprint describes DeepMM, a method that detects suspected misassembly junctions and splits contigs before microbial genomes are grouped into bins. In benchmark datasets, this reduced gene annotations that disagreed with sample-matched reference genomes.
science
A bioRxiv preprint presents LongPhase-TO, a long-read method for reconstructing somatic haplotypes from tumour samples without matched normal DNA. In tests on eight datasets from six cancer cell lines, the method lengthened haplotype blocks and improved somatic variant-calling scores.
science
A University of Michigan team has introduced AmbientMapper, a computational method that estimates ambient chromatin contamination in combinatorial single-cell experiments. In a bioRxiv preprint, the authors report a 0.19% wrong-genome rate on a 26-genome reference panel and recovery of low-depth nuclei that standard pipelines discarded.