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Khabre desk
Recent reporting, analysis and explainers from the Alzheimer S Disease desk.
science
A bioRxiv preprint reports higher Serpin A3 levels in human brain tissue from cases with cerebral amyloid angiopathy and Alzheimer’s disease than in neurological controls. The protein was also prominent around damaged vessels in one postmortem case of severe lecanemab-associated ARIA.
science
A bioRxiv preprint reports two functionally distinct amyloid-beta intermediate populations in laboratory, mouse-model and human Alzheimer’s brain material. In mice, pharmacologically suppressing the intermediates reduced plaque burden and astrogliosis and improved cognition.
science
Researchers have identified a measure of cognitive resilience that helps explain why people with similar Alzheimer’s-related brain pathology can develop dementia symptoms of different severity. The finding could improve understanding and prediction of Alzheimer’s dementia risk.