Search articles by title, topic or section.
Khabre desk
Recent reporting, analysis and explainers from the Biomedical Research desk.
science
A bioRxiv preprint reports cryo-EM structures of human THIK1 bound to two chemically related inhibitors. Both occupy the same pore site, but structural and electrophysiological results indicate that they affect a second channel gate differently.
science
A bioRxiv preprint found no measurable change in arousal when focused ultrasound was applied to the central lateral thalamus of two anaesthetised rhesus macaques. The animals remained physiologically stable, while the authors propose testing more distributed stimulation in future studies.
science
A bioRxiv preprint of 47 patients links phase-specific brain activity and connectivity patterns to early and later language recovery after ischemic stroke.
science
A bioRxiv preprint reports that parvalbumin interneurons and dentate-gyrus changes shape seizure susceptibility in Angelman syndrome model mice. The findings point to altered inhibitory control and homeostatic plasticity as possible drivers of epileptogenesis.
science
A bioRxiv preprint reports a Tris-EDTA-supplemented photobleaching workflow that reduced autofluorescence by 58–70% in fresh-frozen aged human brain sections while preserving tissue architecture and cellular content. The study also introduces a 28-plex antibody panel for spatial proteomics.
science
A bioRxiv preprint describes ST9, a designed peptide that binds claudin-5 and produces a rapid, transient and reversible increase in blood-brain barrier permeability in reported cell-based experiments.
science
A bioRxiv preprint reports that brain-originating dopaminergic neurodegeneration can produce persistent NaV1.7-dependent hyperexcitability in peripheral sensory neurons in a preclinical Parkinson’s model. Blocking NaV1.7 or disrupting its CRMP2 regulation reduced pain-like behaviours, while human Parkinson’s DRG profiling found related excitability-gene changes.
science
A bioRxiv preprint reports that six days of audiovisual timing training reduced susceptibility to the sound-induced flash illusion in both children with ADHD and typically developing children. A Bayesian model indicated that the groups reached this similar behavioral outcome through different changes in perceptual precision and causal expectations.
science
A bioRxiv preprint reports using six-base sequencing to analyse DNA modifications in cell-free DNA released by neural cells into cerebrospinal fluid. The authors say the approach could support liquid-biopsy research into neurodegenerative disease.